Mark's office decorator is murdered.

Young woman is in a car accident and goes blind, Mark must figure out who committed the murder.

A body found on the beach turns out to be Jim, the hospital janitor, but when his twin brother Jeff shows up to identify the body, Mark and Steve become suspicious.

Dr. Mark Sloan tries to save one of his former students, a schizophrenic, from a murder charge, but is challenged by the man's seemingly incoherent babbling.

Steve nearly dies in a car accident and think a murder happens. No one believes him.

A nurse's husband is murdered and a teen who works at the hospital and who also had a torrid love affair with the nurse is the prime suspect, but Mark isn't convinced that the young man is the killer.

An abusive man who, along with four other people, was a contestant on a reality show is murdered while living in a house that is monitored 24 hours a day. After the killing, Mark enters the house as the man's replacement to see if he can uncover what happened.

Mark goes after a man who killed a groom on his wedding day.

Dr. Mark Sloan, Lt. Steve Sloan and Dr. Amanda Bentley become involved when a priest is accused of murdering an old friend.

Dr. Mark Sloan seeks the murderer who killed a med student, drained his blood, and stored him in the Community General morgue.

An actress with an eating disorder dies from an apparent heart attack. Mark believes her nutritionist murdered her.

A young woman is assassinated while Dr. Mark Sloan is examining her, setting off an investigation that plunges Mark into dark memories of his own childhood.

Mark must find out why his dad left him as a child.

Dr. Mark Sloan investigates the apparent suicide of a gifted heart surgeon who was also a compulsive gambler.

Dr. Mark Sloan tries to solve the murder of a young woman whose twin sister claims that Dr. Jesse Travis fathered her infant son.

Dr. Sloan tries to save Jesse and Amanda from a murderer who is out to kill them in order to obtain a multi-million dollar inheritance.

A Tabloid-news paper reporter gets caught up in a murder investigation when one of her sources is stabbed to death on a dance floor.

Dr. Sloan tries to help Amanda when she becomes involved in an incident involving the Chinese government.

Dr. Sloan investigates a controversial attorney who confesses to murder while near death but recants after he recovers.

While deeply disturbed that his son, Lt. Steve Sloan, is falling in love with a woman who is a dead ringer for his murdered former girlfriend, Dr. Mark Sloan begins watching his neighbors through binoculars and becomes convinced that one of them is a murderer.

When a filmmaker begins using Community General Hospital as the location for an eerie documentary, Dr. Sloan discovers it may be haunted.