“We don't get aliens in Sheffield.” In a South Yorkshire city, Ryan Sinclair, Yasmin Khan and Graham O'Brien are about to have their lives changed forever, as a mysterious woman, unable to remember her own name, falls from the night sky. Can they believe a word she says? And can she help solve the strange events taking place across the city?

Still reeling from their first encounter, can the Doctor and her new friends stay alive long enough, in a hostile alien environment, to solve the mystery of Desolation? And just who are Angstrom and Epzo?

Montgomery, Alabama. 1955. The Doctor and her friends find themselves in the Deep South of America. As they encounter a seamstress by the name of Rosa Parks, they begin to wonder whether someone is attempting to change history.

“Something's happening with the spiders in this city.” The Doctor, Yaz, Graham and Ryan find their way back to Yorkshire - and Yaz's family - only to find something is stirring amidst the eight-legged arachnid population of Sheffield.

Injured and stranded in the wilds of a far-flung galaxy, the Doctor, Yaz, Graham and Ryan must band together with a group of strangers to survive against one of the universe's most deadly - and unusual - creatures.

India, 1947. The Doctor and her friends arrive in the Punjab, as India is being torn apart. While Yaz attempts to discover her grandmother's hidden history, the Doctor discovers demons haunting the land. Who are they, and what do they want?

“Delivery for the Doctor!” A mysterious message arrives in a package addressed to the Doctor, leading her, Graham, Yaz and Ryan to investigate the warehouse moon orbiting Kandoka, and the home of the galaxy’s largest retailer: Kerblam!

The Doctor, Ryan, Graham and Yaz arrive in 17th-century Lancashire and become embroiled in a witch trial run by the local landowner. As fear stalks the land, the arrival of King James I only serves to intensify the witch hunt. But is there something even more dangerous at work? Can the Doctor and friends keep the people of Bilehurst Cragg safe from all the forces that are massing in the land?

On the planet of Ranskoor Av Kolos, a battlefield, a conflict-scarred survivor, and a deadly reckoning await the Doctor, Ryan, Yaz and Graham.