The assassination of a seemingly ordinary Brooklyn plumber launches the team into a globe-spanning investigation that ruffles feathers with the CIA.

The team is on the case when a suburban couple is murdered and all forensic evidence points to the home's previous owner, who is currently serving 10 years in federal prison.

When the sister of Sydney Ortiz is the victim of an attempted kidnapping and sexual assault, Sydney seeks help from Isobel and the team in tracking down a meticulous serial offender who leaves no evidence behind.

When a chaotic campus protest turns deadly, the team is called in to help quell the mayhem and track down the murderer. Meanwhile, Jubal is concerned when Tyler is detained along with a group of student protestors.

The team is called in to track down a serial killer after the bodies of multiple women with the same physical description are found scattered across the city. Meanwhile, Maggie juggles her roles as a guardian to Ella and an FBI agent.

After a park ranger is shot dead by a masked assailant on Governors Island, the team discovers a string of connected crimes that leads them to their toughest roadblock yet: an online conspiracy theory community.

After three customs officers are shot dead in a cargo heist, the team entrusts OA's old army buddy Clay to help determine if it was an inside job.

The investigation into an assistant U.S. attorney’s death leads the team to a related airline whistleblower scandal and the chilling discovery that they don’t have much time to thwart terrorists from crashing numerous in-flight commercial airplanes. Dealing with the memory of his brother, who was a 9/11 victim, the case pushes Scola hard to prevent another catastrophe.

Jubal's longtime confidential informant brings intel of an impending large-scale terror attack to the team, but when the details don't add up, Jubal must sift out the truth from a man who's known him at his worst.

When a gunman opens fire at a homeless shelter in Astoria, the team is led toward a killer with connections to a Mexican cartel.

When the team’s sex trafficking sting operation goes sideways, they race to recover a human trafficking victim. Meanwhile, Maggie makes a connection with a 911 operator to help find the girl before she is whisked out of the city or worse.

After two jurors for a high-profile mafia trial are gunned down, the team jumps into an organized crime investigation until it is discovered that the jurors may not have been the intended targets at all. The case becomes personal for Scola when he learns that one of his former drill instructors from the military academy he attended may be linked.

When a passenger train is hijacked and rerouted while at high speed with an unarmed OA and Gemma on board, the team races to wrest control away from the unhinged perpetrators and prevent a catastrophe.

As Maggie and the team search for New York's latest serial killer, the copycat method used by the murderer forces Maggie to seek help from Ray Distefano, the serial slasher she put behind bars.

When an undercover FBI agent is killed in the field, the team makes the unnerving discovery that the identities of multiple undercover agents have been compromised, including Maggie who has been actively working to infiltrate an eco-terrorist group. Meanwhile, the team enlists the help of Special Agent Dani Rhodes, whose cover was also blown, to not only save their own but to aid in uncovering who was behind the leak.

When a famous rapper and two teen fans are gunned down on his tour bus, the team discovers there may be more to the story than his feud with another rapper. Meanwhile, Isobel hits a major milestone that has her contemplating her future at the Bureau.

After two women are brutally murdered via napalm, Maggie and OA are led to a dating site where they discover a group of scorned users who are targeting women who reject them.

After a young girl goes missing in Queens, the team discovers the kidnappers used her as leverage to carry out a major explosives heist, sending them on a hunt for the dangerous culprits. Meanwhile, Scola and Dani begin working on their footing as partners.

When a CEO is killed by a targeted explosion inside his penthouse, the team must work to figure out how someone accessed the highly secure building. Their task is further complicated when they discover the crime may be the work of an artificial intelligence program. Meanwhile, Maggie pumps the brakes on her personal life.

When two IRS special agents are stabbed to death in Brooklyn, the team is thrown into an investigation that leads back to the resurgence of the online conspiracy community of Duke Ducoyle, their suspect from a previous case.

After Jubal narrowly escapes a calculated assault on a secret FBI office, the team discovers a rogue terrorist group has infiltrated the FBI. Unsure of who to trust, the team must work in the shadows to unmask the culprits threatening the sanctity of the New York field office.