After Daphne and Niles elope in Reno, they are forced to go through several fake ceremonies in not to upset friends and family who wanted to be at the wedding.

Frasier drives Niles back from a shopping excursion. Just as they enter the parking garage, Frasier suddenly realizes that the clock in his car is incorrect and that he is going to be late for his show.

Frasier is desperate to finally win the presidency of the condo board after several unsuccessful attempts. However, he admits that he has no chance because he has rubbed all of the board members the wrong way at one time or another.

Frasier is surprised to learn that Kenny has never unpacked the boxes in his office because he views all of his jobs as temporary. Roz's younger cousin Jen comes to stay with her for the week. She is extremely cynical and opinionated, and quickly gets on Frasier's nerves.

Frasier is infuriated when Bulldog successfully pulls several practical jokes on him. He vows to get revenge, and plots an elaborate prank that he takes way too seriously. Martin and Roz predict that he will fail because he is terrible at carrying out pranks. .

As Frasier prepares for Frederick's bar mitzvah, Noel offers to translate Frasier's speech into Hebrew in exchange for an autograph from a science fiction convention. However, when Frasier doesn't keep his end of the bargain, Noel uses his wealth of Star Trek knowledge to take revenge.

Niles becomes concerned about a lingering toothache after his dentist assures him that there is nothing wrong with the tooth. He tells Roz that there is a chance that he may be suffering from referred pain; and that the pain could actually be a sign of a heart condition.

Niles prepares to undergo heart bypass surgery. He is surprised to receive a call wishing him well from Maris, who had learned of his plight from a gossipy acquaintance. Frasier tries to keep Roz and the family at ease by researching the procedure (as well as the doctors' backgrounds) and printing out detailed descriptions for everyone.

Niles recovers rapidly from his heart surgery and receives the go-ahead from doctors to resume normal activities, but seems reluctant to do this. He maintains his strict post-operative diet, and refuses to exercise or share a bed with Daphne.

Frasier and Niles bicker over who gets to host the family Christmas celebration. When it seems that Martin will have to work, they decide to bring Christmas to him, with disastrous results. Meanwhile, Roz finds herself attracted to a hunky shopping mall Santa.

Frasier mistakenly receives some of Cam Winston's mail, including a mysterious invitation to an exclusive locale. Frasier and Niles are surprised to have been left out of the loop about this new hot spot, and become obsessed with finding out more information.

Frasier is forced to give up ten minutes of his show for a new financial analysis segment. When the beautiful new stock market reporter's attitude rubs everyone the wrong way, Frasier misreads her signals, which lands everyone in a sexual harassment seminar.

Lilith comes to Seattle, and tells Frasier that she would like to have another child. She wants him to father the child through artificial insemination so that Frederick could have a full-sibling. Frasier is hesitant to go along with this, so Lilith tries to manipulate him by bringing up touching stories from Frederick's childhood.

Niles and Frasier plan a party to celebrate the unveiling of a painting that Niles has just purchased. However, Daphne notes that every event the brothers host inevitably ends in disaster.

Tired of being humiliated in his club's annual squash tournament, Niles ditches Frasier and pairs with a younger partner. A P.E. teacher named Chelsea asks Frasier to team with her in the mixed doubles competition.

KACL organizes a bike-a-thon to raise money for AIDS research. Frasier plans to just make a financial donation, but is goaded into participating after Julia announces her intention to take part. Daphne suggests that she and Niles also enter the event.

Kenny becomes extremely depressed after his divorce is finalized. Frasier offers to refer him to another psychiatrist, but Kenny says that he would prefer to discuss his problems with Frasier.

Frasier's co-workers cajole him into helping them build a house for Habitat for Humanity. Frasier mostly seems to get in the way, and his participation is limited to stirring paint and a little bit of sanding.

Frasier consults his old friend Avery for advice on his finances. Avery says that Frasier's spending habits are out of control. Frasier becomes depressed and heads out to Cafe Nervosa to think about a solution.

Frasier learns that Dr. Phil McGraw is in town for a special. The two are old friends, but Frasier is angry at Phil for supposedly swindling him out of $200 in a poker game. He reluctantly agrees to take the star-struck Roz to the set to see him.

Leland Barton, Hester's former research assistant, comes for a visit after a long absence from Seattle. Roz becomes alarmed when Leland confesses his deep affection for Hester.

Julia becomes extremely depressed after breaking up with Avery, who had never followed through on his promise to leave his wife for her. He tries to deny her the credit for their software company, an endeavor for which she did most of the work.

Roz tries to train the woefully incompetent Noel as Frasier's new producer as she prepares to leave KACL. She becomes increasingly melancholy about the possibility of leaving Frasier, and bristles upon learning of his new relationship with Julia.