The doctors of Seattle Grace are faced with the aftermath of last season's plane crash. As they try to move on with their lives, they must learn to adapt to the changes, cope with their losses and move forward with their relationships and careers.

The survivors from the crash are asked to make an almost impossible decision that will affect the rest of their lives. Meanwhile, tension grows between Jackson and April after they're forced to work together, and Alex tries to restrain himself with one of the interns.

Aware that Derek might never operate again, Meredith stops talking about the surgeries she's performing. Meanwhile, Richard calls on Dr. Catherine Avery to help him perform a complicated procedure, as things continue to heat up between Jackson and April; and Arizona's struggle to accept her fate forces Callie and Alex to face their guilt.

In this Meredith & Cristina-centric episode, the two friends continue to cope with life after the plane crash and their ever-growing responsibilities at their respective hospitals. As Meredith juggles taking care of Zola with a case that hits close to home, Cristina assists Dr. Thomas on a challenging heart surgery.

As the doctors continue with their lawsuit, they’re forced to confront the realities of their injuries. Meanwhile, Bailey tricks Arizona into helping her with a pediatric case, and Cristina tries to find normalcy in her new environment.

Cristina and Owen continue to figure out their relationship amidst the pending lawsuit; and Bailey argues with Ben over plans for their upcoming nuptials. Meanwhile, Callie recruits Jackson to help find a solution to Derek's hand, but he is preoccupied by a shocking situation with April.

The new batch of interns find themselves involved in all the drama at Seattle Grace: Meredith asks Heather to go above and beyond to help fix Derek's hand; Cristina starts a healthy competition between Stephanie and Leah, which inadvertently leads to a medical emergency for Cristina's patient; Alex sees Jo in a new light as they work to save a baby's life, and April teaches Shane a valuable lesson during "lumps and bumps" duty.

As the rest of the doctors prepare for Bailey's wedding, Richard helps her through a bout of pre-wedding jitters. Meanwhile, Lizzie butts heads with Meredith, and Callie and Jackson try to convince Derek to participate in a risky surgery that could fix his hand.

Bailey puts her wedding day on hold and continues her efforts to save Adele's life, Cristina and Owen remain undecided about their pending divorce, while Arizona and Callie try to get their spark back. Meanwhile, the hospital becomes inundated with a group of bikers after a horrible accident.

Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark Sloan's old patients. Meanwhile, Derek begins recovery on his hand.

The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.

As Derek and April work around the clock to find a solution for the hospital, Cristina struggles to respect the wishes of a family whose son is dying. Meanwhile, Arizona empathizes with a teenager who faces problems similar to her own.

Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.

As the hospital spirals closer to financial ruin, Owen must make some tough decisions, which includes foregoing an expensive surgery that could save the life of a child. Meanwhile, Alex and Jo work together to save the life of an infant, and April asks Jackson for dating advice.

As word of Seattle Grace's financial trouble spreads, Catherine encourages Jackson to move to Boston, and the interns fear they might lose their jobs. Meanwhile, the doctors meet with a potential investor in a last-ditch effort to save the hospital, and Alex impresses Jo while caring for a patient.

The discord and chaos created by the hospital's new management team causes one physician to question his future at Seattle Grace. Meanwhile, the doctors and the interns must juggle several transplant surgeries at once, each coming with its own set of obstacles.

As the hospital continues to make positive changes under the new management, the doctors begin to realize that owning a hospital comes with its own set of problems and responsibilities. Meanwhile, Meredith worries about the wellbeing of her unborn baby, Callie and Arizona try to get the spark back in their relationship, and Alex gives Jo‘s new boyfriend a run for his money.

A gas tanker explodes on a Seattle highway, causing multiple injuries, including paramedic Matthew. Meredith and Jo help a frantic mother whose child is suffering from a mysterious illness. Owen bonds with a young boy whose parents are in critical condition. Meanwhile true colors are revealed when Alex is forced to work with Jo's boyfriend on an ailing patient.

Upon receiving some unsettling news, Meredith and Derek take preventative steps for their children’s future; a group of Syrian doctors arrive at Grey Sloan Memorial Hospital for a crash course in basic surgical skills that they plan to apply in the field; and April decides to come clean to Matthew regarding the truth about her virginity. Meanwhile, multiple pre-op patients develop infections, causing one doctor to wonder if she is at fault.

Bailey finds herself at the center of a CDC investigation surrounding the death of several of her patients, as Jackson and the rest of the board members argue over how to address the crisis with the public. Meanwhile, Cristina teases Alex about his unspoken feelings for Jo, and Owen continues to take special care of Ethan as the condition of his parents remains uncertain.

The doctors reach out to Bailey but she continues to shut everyone out; after an incident with Ethan's grandmother, Owen fears the child could end up in foster care. A new craniofacial specialist arrives at Grey Sloan Memorial Hospital to work on a young patient. Meanwhile, a magician's assistant is rushed into the ER after a magic trick goes terribly wrong.

The doctors of Grey Sloan Memorial Hospital prepare for a super storm heading towards Seattle. Owen's desire to be a parent gets stronger as he becomes closer to Ethan. One wrong move puts the lives of Meredith and her baby in jeopardy. Meanwhile, Jo looks to Alex for help in a moment of crisis, and one doctor gets the shock of her life.

Grey Sloan Memorial Hospital enters crisis mode as the storm rages, resources become scarce and patients flood in by the busload. Meanwhile, one of the doctors fights for their life.