In 1987, in Japan, a boy named Jotaro Kujo has willingly turned himself into jail, refusing to leave. Jotaro's mother, Holly, requests help from her father, Joseph Joestar, who travels to Japan alongside an acquaintance, Mohammed Abdul.

Jotaro heads to school and encounters a mysterious transfer student named Noriaki Kakyoin.

Jotaro is able to defeat Kakyoin. He takes the wounded Kakyoin back to his house, hoping to get some information about DIO.

If they do not defeat DIO within 50 days, Holly could die - Jotaro and crew head to Egypt, where they think DIO is hiding. While on the plane, they run into another one of DIO's assassins.

DIO's next assassin, Polnareff attacks Jotaro and crew, Abdul faces him with his Magician's Red.

With a new person in their party, they head to Singapore with the boat the Speedwagon Foundation provided them, during their journey Jotaro is targeted by an enemy Stand from within the water.

Arrived in Singapore, Jotaro's group stays at a hotel individually. A new Stand owner who is known as "Devo the Cursed" is awaiting Polnareff in his room. Devo's Stand increases its power as its user's hatred towards the opponent increases. Polnareff gets into a desperate situation as he starts fighting front. Does Polnareff have a chance to win the battle against Devo who keeps attacking him in a cruel and brutal way?

Joseph uses Hermit Purple to create a message using the TV, which tells them that Kakyoin is a traitor.

The group travels to India. In a restaurant Polnareff is attacked by a mysterious Stand that is inside a mirror.

In an effort to save Polnareff, Abdul is injured by the enemy. Then J. Geil's Stand, Hanged Man attacks.

The group heads toward Varanasi. On the way, Joseph realizes his arm is quite swollen.

Jotaro and the others head toward Pakistan in a car. Polnareff is driving the car on a very dangerous mountain road, and recklessly passes a slow moving vehicle that was in front of him.

Jotaro and the others successfully survive another attack from the enemy Stand users and make it into Pakistan. However, they decide to find an inn at a nearby village because of the dense fog they suddenly hit. The village they get to is rather quiet and all of the inhabitants seem rather odd.

Polnareff finally realizes that Enyaba is another assassin from DIO. He tries to warn the others, but Enyaba's Stand, Justice, has the ability to take control of people's bodies and corpses, and he is pursued. The whole village had already been under Enyaba's control.

After surviving Enyaba's attack, Jotaro and crew make it to Pakistan's capital, Karachi. There, they encounter DIO's next assassin, Steely Dan. Following DIO's orders, Steely Dan ruthlessly kills Enyaba in front of them. Jotaro and the others can't help but feel conflicted about that happening, and end up in a battle with Steely Dan.

Steely Dan's Stand, The Lovers, has entered Joseph's brain. Dan puts himself at an advantage, with having Joseph's life on the line, and tells Jotaro to do various things for him, knowing Jotaro has no choice but to obey. Meanwhile, Kakyoin and Polnareff also enter Joseph's brain with their Stands and find the Stand that is using brain cells as food.

Jotaro and the others continue their journey through the desert, trying to get to Cairo. They travel with camels and can't shake the feeling that someone is following them, but no one is in sight. Traveling in the killer heat, they realize that it's still bright out at 8pm and the sun is actually rising rather than setting.

Kakyoin is dreaming and dreams about being in a strange amusement park, where he encounters the Death tarot card. While in the dream, he witnesses Death 13 cut down a dog. Kakyoin wakes up screaming, but can't remember what his bad dream was about.

Kakyoin tries to convince the others that the baby is suspicious, but that backfires and his friends start to doubt his sanity. Kakyoin then tries to convince them that he's not crazy, and shows them his arm that has "Baby Stand" carved into it... but that just makes them believe he really is crazy. Kakyoin then tries to use his Stand to attack, but is knocked out by Polnareff. Eventually, Jotaro and the others wake up in the nightmare and the truth finally comes out.

While on an island on the edge of the Red Sea where Mohammed Abdul's father is said to live, Polnareff uncovers a magic lamp and its genie Cameo offers him three wishes, although all is not as it seems. 

Polnareff must find out a way to escape the attacks of Cameo and his Stand Judgement who has apparently turned his sister Cherie and Abdul into zombies.

Jotaro and the others obtain a submarine as a new means of travel. Through the Red Sea, they try to head toward Egypt where DIO awaits. Using the sonar to detect any threats on the outside, the submarine quietly dives in. They however realize that if they're attacked underwater, there is nowhere to escape, so they are on their guard. Finally, when they are about to surface, a coffee mug that was in the cabin transforms and cuts off Joseph's artificial hand.

The group must find a way off of the submarine and away from the attacks of High Priestess. 

Jotaro's group encounters N'Doul's Stand "Geb", and Iggy's "The Fool".

The group's encounter with "Geb" and "The Fool" continues.

As the Joestar group arrives in Aswan they encounter Oingo's Stand "Khnum" and Boingo's Stand "Thoth".

Jotaro's group encounters the Stand "Anubis".

The encounter with the Stand "Anubis" continues.

Jotaro and the others arrive in Luxor. While heading there, Joseph notices an electrical outlet in a rock. Obviously fascinated by the electrical outlet in the rock, Joseph gets closer, and he gets shocked.

Due to the powers of an enemy Stand, Joseph's body becomes magnetised. While chasing after the woman that seemed to be the Stand user, Abdul also touches the electrical outlet and becomes magnetised as well.

While Joseph and Avdol were fighting with Mariah, Jotaro gets concerned that they haven't shown up yet, and goes to look for them around Luxor. Then, Polnareff senses someone following them and confronts the man.

Because of the power of Alessi's Stand, Set, Polnareff is turned back into a child. The one who came to his aid amidst his confusion was a woman named Marena. However, Alessi's evil hands followed Polnareff into her house.

After a long journey, Jotaro and the others finally reach Cairo. They go to a cafe and ask if anyone knows where DIO's mansion is located by showing the picture around. Then, someone says that they have seen the building before.

Souls are on the line as a game of poker continues.

Hol Horse arrives at Cairo in order to pursue Jotaro and the others. He has joined forces with another partner and is after the lives of Jotaro and crew once more. That partner, is none other than Boingo.

Hol Horse and Boingo followed Jotaro and the others to Cairo and as Boingo's book said, Hol Horse stuck his fingers into Polnareff's nose... but he didn't know what to do from there. Then Jotaro and the others, who were looking for Polnareff, show up, but things seem to be going the opposite way of the premonition.

Jojo and the others continue to look for DIO's mansion in Cairo. Following Abdul's advice, they have a beggar look for the mansion and wait. Meanwhile, Iggy, who is wandering the city alone, gets confronted by two large dogs. The dogs are freaked out by Iggy's power, and decide to go after a bird that's at a nearby mansion instead. However, as soon as the dogs go into the mansion, they are impaled by a giant icicle. Iggy is shocked by the occurance, and sees a falcon appear...

Iggy ends up in a battle to the death in the sewers against the falcon that guards DIO's mansion, Pet Shop. Pet Shop shows no mercy, and goes after Iggy at a frightening speed. Iggy, despite being injured, runs into the river, making a dome made out of dirt to shield him. However, he underestimates Pet Shop's abilities, and...

Despite Iggy's injuries, Jojo and company finally make it to DIO's mansion. Once they entered, a butler named D'Arby the Younger was awaiting their arrival. The younger brother of the defeated D'Arby the Elder, he immediately shows off his Stand, Atum's power.

The battle for souls with D'Arby continues. Kakyoin challenged D'Arby to a race game, but ends up losing and D'Arby steals his soul. Before Joseph really has time to react, Jotaro picks the next game.

The baseball match with D'Arby continues within DIO's mansion. For some reason, Jotaro starts declaring his pitches to D'Arby. D'Arby finds Jotaro's actions strange, but still believes he has the upperhand because of his Stand's abilities.

After a long, hard journey, they are faced with a sudden goodbye of a friend. Because it's so sudden, Polnareff can't control his emotions. He starts brandishing his sword toward the unseen enemy with very little success.

Polnareff is pushed to his limits with Vanilla Ice's merciless attacks. He finally awaits death, but is saved at the last minute by the dying Iggy. Iggy uses the last bit of his energy, but his Stand is obviously losing power. Polnareff then stabs Vanilla Ice in the head. Despite showing resilience to the attacks so far, Vanilla Ice is finally destroyed.

Polnareff encounters the Stand "The World".

The group tries to identify DIO's Stand.

The fight continues.

The final battle!