Daisuke Yamamoto, a young Japanese man raised in the wild Amazon jungle, is forced to become Kamen Rider Amazon to fight the Gedom, who are now eying Japan for conquest.

Amazon continues to face problems in society and be scorned for Gedom's actions just as he encounters a motorcyclist who wishes to help him.

Amazon tracks down a colleague of Professor Okamura in hopes to find out more information about Gedom.

Amazon continues to bemoan his problems while being pursued by a strange beastman mole sent by Gedom.

Amazon and Mole Beastman become further connected when protecting a mysterious Incan rope-message with the secret of Gedom.

As Amazon battles Snake Beastman who was sent by Geddon to after Amazon through Hiromi and her biologist father, Professor Seichiro Arima.