On 22 August 1985, an engine of British Airtours Flight 28M fails during takeoff, puncturing a hole in the wing fuel tank and starting a fire. The crew successfully abandons the takeoff and stops the aircraft on the runway, but the fire spreads to the cabin. 55 people die before they can evacuate, mainly due to inhaling toxic smoke. The investigation found that fatigue of a part in the engine caused it to fail.

On 16 August 1987, Northwest Airlines Flight 255 stalls as it lifts off from Detroit Metropolitan Airport and crashes just beyond the runway, killing 154 of the 155 people on board and two people on the ground. The investigation showed that the pilots failed to configure the aircraft's flaps and slats for takeoff.

On 1 February 1991, USAir Flight 1493 collides with a waiting SkyWest Airlines aircraft on the runway, killing 34 people. An air traffic controller mistakenly assigned the inbound Flight 1493 to land on a runway where SkyWest Flight 5569 was waiting to take off.

On 1 September 1983, during the Cold War, Korean Air Lines Flight 007 was shot down after violating Soviet airspace. The crew did not switch the autopilot from heading to INS mode following take off which caused the aircraft to deviate from its assigned flight path.

On 10 March 1989, Air Ontario Flight 1363 crashes just after takeoff, killing 24 people. Three years later, on 22 March 1992, USAir Flight 405 also crashes just after takeoff in similar conditions to Flight 1363. The cause of the crashes was ice on the wings, which significantly reduced lift.

On 20 January 1992, Air Inter Flight 148 flies into a peak in the Vosges Mountains while circling to land at Strasbourg Airport, killing 87 people. An error made in programing the aircraft's autopilot, combined with a sudden wind change, caused it to descend more rapidly than expected.

On 19 December 2005, just seconds after takeoff from Miami, Florida, the right wing of Chalk's Ocean Airways Flight 101 breaks off, causing the aircraft to crash into the sea, killing all 20 people on board. The causes of the crash were metal fatigue and poor maintenance.