Bruce Chapman returns home early from a business trip to find that his wife, Marie, wants a divorce. Chapman is shocked at this turn of events because just before he left on his trip he thought he had found the strangled body of Marie in his office. But if Marie is still alive, who was the dead woman in the office?

Lorna Thomas is a has-been actress who once gave up her baby for adoption and lived to regret it. George Clark discovers that his wife might be Lorna's long-lost daughter and begins to see dollar signs.

Larry Benton is a hard luck guy. When he gets in an argument in a poker game and knocks Mike Granger out cold, his "friends" inform him that Granger is dead. Unbeknownst to Larry, the entire scenario is a scam to shake him down for money. Ring leader, Johnny Clay, ends up dead.

Mitsuo Kamuri has been seeing a great deal of Grover Nichols, son of wealthy businessman Hudson Nichols. Nichols doesn't approve of his son's relationship, and when Mitsuo is "caught" with a string of valuable pearls belonging to Mrs. Nichols, he agrees to drop all charges provided she stops seeing his son. Things then get even more complicated when Mitsuo's uncle is found murdered.

Wealthy rancher John Brant forecloses on Jo Ann Blanchard's mortgage and takes possession of her prized stallion. Jo Ann goes to Perry for help in getting the horse back but soon needs Perry's aid in getting her off a murder charge she is arrested for killing Brant.

Frank Thatcher is involved in a hit-and-run accident but does not report it. He uses Paul Drake to take care of the aftermath of the incident. Later, Thatcher is found dead in the same apartment with Paul, after he wakes up—and Paul’s accused of the murder.

Richard Vanaman is up for a promotion at his investment firm but is sabotaged and framed for murder.

Wally Dunbar seeks Perry's help in securing ownership of his new summer line of swimwear but the sketches are stolen and worse yet, chief designer Rick Stassi is murdered. Wally's girlfriend, Kitty Wynne, who was being blackmailed by Stassi goes to trial for his murder.

Allen Sheridan has more enemies than you can shake a stick at—and he's due to inherit the healthy sum of $162,000.00. When Allen turns up dead, his cousin Sarette becomes the prime suspect.

Marjorie Cluny wins a contest for best looking legs sponsored by Frank Patton of Stellar Productions. Her prize is a trip to Hollywood and a role in Patton's next picture. Unfortunately, there was fine print in Marjorie's contract and her Hollywood career lasts only two days. Patton is then found stabbed to death with a woodcarving instrument . Marjorie disappears and becomes the leading suspect.

Perry goes on a fishing trip in a small Sierra Nevada town with his old friend, Sheriff Gene Norris but, as usual, manages to get sidetracked into another murder case when Phil Beecher returns from jail.

A double cross, a double murder, a plane crash, missing money, and yet another innocent widow charged with crimes she didn't commit are the elements of this case.

Ben Sutton is listed as the author of a best-selling book describing his experiences in a Korean POW camp. When the real author is released from an Army hospital, Sutton is slain before he can tell the truth and his widow is arrested for the murder.

DA Hamilton Burger asks Perry to defend an old friend who once saved his life in a boating accident ten years before. The old friend of Burger's is now facing a murder charge.

Corporate intrigue is the backdrop of this episode, when embezzling accountant Robert Doniger is murdered and Edward Nelson is charged with his murder.

Charles Houston cleverly gets away with killing his wife by making it look like she died in a car accident. Then a wildlife photographer shows up with the murder on film, and Charles discovers that his sister-in-law has squandered all the profits from his oil well.

Author Mauvis Meade sends her secretary, Gladys Doyle, out to a mountain cabin to pick up a package. Gladys gets lost and her car gets stuck in the mud. She then walks to a cabin looking for help and encounters a mysterious man who appears to know her. While Gladys freshens up, the man leaves and Gladys discovers a dead body.

The Big Barn is a gambling casino run by George Anclitis. Things are going well at the Big Barn, until George's second banana, Slim Marcus, botches a crooked card game and is exposed for cheating. Slim's girlfriend, Vivan Ennis, is then murdered.

A valuable Matisse painting is stolen from a museum. When the thief is found murdered museum employee June Sinclair and her boyfriend David Lambert are charged with the crime.

Mason is sought out by land tycoon Adam Thompson, who suspects one of his nephews of rifling the house safe. The twist? The land tycoon's next in command is found dead, after it's found out that he was the one stealing the secrets.

After one of the biggest names in fashion is poisoned after embarassing her husband on TV, the husband is not rightly the prime suspect.

Commander Jerome Burke is assisting the police in the investigation of the murder of a café singer. Later, Commander James Page is found dead in the captain's quarters of the Navy submarine, MORAY. Robert Chapman, a sailor who was married to the deceased singer, is accused of both murders.

When a notorious bank robber's son returns to his hometown it seems as though everyone is interested in missing loot supposedly hidden by the man's father. This leads to murder. Perry comes to the rescue once again.

James Frazer wants a divorce and his cheating wife refuses to give him one. She's also stealing the plans to his invention in order to bait her engineer lover into staying around. Frazer leaves town for three months in order to cool down, but on the night of his return he finds his wife murdered in his office—and he has the only key to a unique, burglar-proof lock that he invented.

18 year-old Trudy's mother has died leaving her $10 million and suddenly men claiming to be her long-lost father are coming into town. The only one who could identify the real father, a blind uncle, is killed, but by who?