Sam and Dean are left to pick up the pieces after the loss of their mother, the demise of Crowley and the heartbreaking death of Castiel. The birth of Jack leaves the Winchester brothers with differing opinions on how to deal with a Nephilim. After being dragged into the breach, Mary must learn to survive Lucifer and an apocalyptic world.

Sam and Dean begin to explore what Jack is capable of doing with his powers. An unexpected visit from Donatello alerts the boys to the fact that Jack will need more protection than the Winchesters can provide. There is a new Prince of Hell in town, Asmodeus, and with Lucifer out of the picture, he sets his sights set on Jack.

When her friend is murdered by a wraith with a taste for psychics, Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, who has no idea she shares her grandmother’s trait and could be next on the wraith’s hit list. Meanwhile, Sam continues to work with Jack on learning how to control his powers.

When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.

While working on a case involving the ghost of a demented doctor, Sam and Dean get assistance from an unexpected source. Castiel finds his way back to the Winchesters.

Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.

As Sam and Dean continue their search for Jack, with Asmodeus hot on their trail, they stumble across a familiar foe. Meanwhile, Lucifer manages to escape Michael’s grasp and finds himself an unlikely and mostly unwilling ally.

Sam and Dean join the crew of a heist on behalf of a Crossroads Demon who has offered them a spell that can track Nephilim.

Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dreamcatcher named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.

When Sam and Dean go missing, Jody Mills calls Claire Novak, the rebellious rogue hunter, and tells her it is time to come home – they need to find the Winchesters. Claire returns and reunites with Alex Jones, who has stayed behind with Jody and tries to balance a “normal” life with being a part time hunter. While Jody is happy to have Claire home again, she’s plagued by Patience’s disturbing vision involving her adopted daughter. Claire and Alex search for Kaia Nieves, the dreamcatcher responsible for opening the rift that Sam and Dean went through, as she holds the key to their whereabouts. Jody calls her friend, Donna Hanscum, to round out the team and the women head off on the most important hunt of their lives.

Donna calls Sam and Dean for help after her niece, Wendy, goes missing. The three hunters discover Wendy was kidnapped by a man who sells human parts to monsters in a grotesque online auction and race to save her before it is too late.

Dean falls victim to a couple of witches, sisters Jamie and Jennie Plum, who manage to steal a powerful book of spells from the Winchester brothers. When Sam and Dean go after the book, they get help from a powerful and surprising ally when Rowena, back from the dead, intervenes to assist them.

Sam, Dean and Castiel search for Lucifer who, meanwhile, strikes an unlikely deal with a local faith healer named Sister Jo. Asmodeus inches closer to finding Jack.

Jack and Mary manage to escape Michael’s clutches and end up finding an ally in “apocalyptic world” Bobby Singer. Meanwhile, Sam, Dean and Castiel continue to search for a way to open a breach, not realizing that one of their own may be working against them and costing them precious time.

Sam and Dean are close to collecting everything they need to open a rift into the Apocalyptic World and possibly rescuing Mary and Jack. The one missing ingredient leads the Winchesters to a black market for religious relics where everything is not always as it seems.

Sam, Dean and Castiel are transported into the animated world of Scooby Doo where they join forces with the Scooby gang to solve a ghostly mystery.

Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.

Lucifer rules over heaven but things aren’t going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.

Sam and Dean must stop Rowena, who is on a deadly mission. Meanwhile, Castiel looks to heaven to recruit angels for an impending invasion but is shocked by not only what he finds, but who.

Gabriel is back and drags Sam and Dean into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's inflating confidence leads to reckless decisions that could put others in harm's way.

Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena’s encounter with Lucifer may alter the outcome of the journey for one of our heroes.

Our heroes, Sam and Dean Winchester, continue to be tested in the battle between good and evil, but one impulsive decision could alter the lives of one the brothers forever.