Earp and Doc capture a very young female outlaw called Little Pistol while tracking a band who robbed Doc's saloon. She likes Earp but refuses to talk until Doc uses nitrous oxide to pull her impacted wisdom teeth causing her to open up.

While away for the day helping Sheriff Masterson, Earp appoints Hal Norton as his Chief Deputy. Hal is forced to confront several problems while Earp is gone. He recalls how Earp would act in similar cases in deciding on what to do.

Texan Drum Denman goes after northerner Earp by backing a free newspaper to print false stories about Earp trying to draw him out of Dodge City. His second story says Earp is having an affair with the minister's teenage daughter.

Custer's widow is worried about an upcoming hearing on Major Reno's actions during Custer's last stand. A civilian scout for Reno at the battle is trying to blackmail her. They meet at Dodge City where Earp tries to intercede and help her.

A boxing promoter comes to Dodge City challenging men to fight "Champ" Starbuck for money. Local businessman Moresby is willing to pay the promoter $500 if the "Champ" fights Earp and severely injures him while a youngster wants a chance.

There have been repeated attacks on the Wells, Fargo coaches running from Hays, Kansas to Dodge City. To Wyatt Earp, an old and trusted former employee, comes the request that he again ride shotgun over the line and thus put renewed confidence in those who shipped money by Wells, Fargo. But the order only served to bring out the guilty verdicts in renewed force, for they were anxious to get Earp, their greatest enemy in the state.

Wyatt Earp's two Indian friends, Mr. Cousin and Mr. Brother, have information about four notorious murderers, The Dry Gulchers, when they intercept the Indians and kill one of them. Earp swears he will run them into the ground and in ""One"" he starts and is successful in part of his quest.

Wyatt Earp continues his search for the remaining three men (he has already bagged one) who killed his Indian friend, Mr. Brother. But this time Wyatt and Bat Masterson, in addition to chasing the Dry Gulchers, has to contend with a group of Cheyenne and a young Army lieutenant still damp behind the ears. But Wyatt bags number two of his query. Two down, two to go.

When the notorious Dry Gulchers killed one of Wyatt Earp's Indian friends, Mr. Brother, they brought upon themselves Earp's relentless pursuit. Now two of the Dry Gulchers have been caught, the chase is well into Texas and Wyatt has enlisted the aid of the Texan Rangers as the third captive is sought.

Ben Thompson sneaks back into Dodge City bringing trouble and two women who were both promised marriage by him. Earp becomes entangled in the problem when he is caught with both women fighting in his hotel room while Doc finds a solution.

The last of the notorious Dry Gulchers, sought by Wyatt Earp, because he is one of a group which murdered his Indian friend, Mr. Brother, is hardest of the group to catch. He is protected by a father and daughter in a ranch deep in Texas. And the mixture of man and women against Wyatt proves almost his undoing. The death of Wyatt's Indian friend is avenged.