When Victor Freemantle, a dangerous revolutionary, steals the U.S. Constitution, agents James West and Artemus Gordon are sent by the government to the Panhandle Strip in Texas to recover it. West and Mr.Grigsby, a curator of the United States Archives, go to a secret underground hideout where Constitution is being held to verify the authenticity of the document. After determining that it is the genuine article, West and Grigsby are presented with Freemantle's demands: They are requested to cease negotiations with Mexico and the U.S. is to recognize the Panhandle Strip as a Sovereign enclave between the borders. A one-millon dollar ransom in gold must also be paid. As part of their agreement, Freemantle holds Grisby hostage until West returns. But West and agent Artemus Gordon decide to ignore the demands and rescue the Constitution themselves by infiltrating Freemantle's castle; Gordon disguises himself as a whiskey salesman and West hides underneath his wagon.

On a mission for President Grant, agent West travels to Fort Savage to meet with a Major Jason and help prevent a revoloution in Canada that outlaw Shawn O'Riley has plans to incite. At the fort, West reads a description of O'Riley and realizes too late his striking resemblance to Major Jason. O'Riley announces that he now controls the fort and is holding the real major and his men captive. Meanwhile, Gordon has gone under cover to learn the details of the revolution. He arrives at West's side just as his partner is trapped on wrong side of O'Riley's gun.

As United States and Mexican border relations are becoming stained,West and Gordon disrupt an assassination attempt on the Mexican President. While returning the captured assassin to Texas,they are fired upon by Mexican soldiers who are led by the merciless Colonel Barbossa. The assassin,just before he is captured,is given a pill by Gordon that makes him appear dead. Then Gordon,disguised as a priest in a wagon,goes to the prison to pick up the dead prisoner.

The agents travel to Hayes City to identify the body of their archnemesis, Dr.Loveless. While there, they meet up with Miguelito's next of kin, Dr.Liebknicht, a Swiss neurologist. However, as they pursue the origin of a key found on the body, they find that Loveless is hardly dead and has plans to use his neurologist guise to give Jim a lobotomy!

James and Artemus arrive in Mexico with a present for the Mexican president-a beautiful Arabin horse. Within minutes of their arrival,however,the horse os stolen by a group of outlaw babdits.Our heros must battle the hot mexican desert to get the horse back before the outlaw Mexican ary beats them to it.

The U.S. State department is about to return a valuable samurai sword to its rightful owner,a Japanese prince,when it is stolen by an group of sword-wieding assailants. Jim and Artemus must located the sword and return it to the prince before he leaves the next afternoon,or risk damaging U.S.-Japan relations.

During a stopover in a small Kansas town, the agents become involved in a murder investigation. After a man is found guilty and sentenced to hang, the agents uncover valuable information that points in an entirely different direction. Of course, this information puts our agents into quite a bit of danger, but, as we know, they can handle themselves relatively well in these sorts of situations.

An ancient Aztec map leading to the lost treasure of Montezuma is discovered in Mexico and points to a location in Texas. In order to ensure that a diplomatic incident does not ensue,West and Gordon team up with Colonial Sanchez of Mexico and a noted archeologist in a dangerous trip across the Texan desert in search of the treasure.

Counterfeit money is appearing in an area around Denver in sufficient quantities to undermine the U.S. enconomy. West and Gordon attempt to track down the source of the fake currency before it's too late.

James West and Artemus Gordon help evacuate the town of Tonka Flats before it is destroyed by a cannon shell. Afterwards, they are notified that a man identified as "The Falcon" has threatened to obliterate Denver unless the U.S. government pays him $1,000,000. "The Falcon" is also in cahoots with syndicate leaders from Turkey, Spain, Prussia and England. During their investigation, Gordon is threatened by a whip-wielding Spaniard named Munez who suspects Gordon knows too much about the top secret weapon. West rescues Gordon from Munez, who is then killed by an explosive meant for the two agents. While searching Munez's body, West and Gordon find an invitation from "The Falcon". Gordon, disguised as Munez, prepares to attend the meeting while West attempts to penetrate the stronghold where the cannon is housed.

Something is happening in the small town of New Athens. residents are leaving in droves,scared off by a band of seedy cut-throats gathering just outside the town limits. And then there's Michael Trayne,back in town after three years in jail. Can Jim and Arte figure out what's happening and save the town before everyone leaves permanently?

West and Gordon take on the power-crazed secretary to a Territorial Goveror. The secretary controls the Governor and has plans to take over the US Goverment and the Presidency as well. To make things more difficult, his Black Legion troops do not take kindly to the two agents interferring.

The stress of Secret service work appears to be finally getting to Jim as his temper flares and he makes mistakes. As West is being recruited by some member of the underworld who seeks to capitalize on his misfortune,Artemus and Conel Richmond struggle to find out exactly who,for what,and why.

At the request of the Bosnian government, Count Draja is to be turned over for extradition. Learning of a plot to free the Count, Jim and Arte make plans to see that Draja reaches his destination. While Jim escorts Draja through 100 miles of no-man's land, they'll all meet up in Buffalo Springs-but there is the little matter of the $500,000 the Count hid somewhere in the U.S.

Agent James West attempts to rescue a man called Mr.Markham from a masked assailant who flees the scene of the crime. As Markham lays dying,he utters two words-""enzo"" and ""silver"". Meanwhile,Agent Artemus Gordon has joined a troupe of entertainers traveling to Denver under the leadership of casino operator Kohner. Gordon,who is posing as a Shakespearean actor,learns that a man called Enzo has a girl friend,Topaze. She is a dancer with the troupe,probably working under an assumed name,and is on her way to meet Enzo in Denver. Dierdre,a dancer,attempts to pass some information to West but a jealous Kohner interrupts them and engages the agent in a fight with him and El Bardhoom,a huge weight lifter. Later,Artemus hears a strange voice of Markham's masked Killer. When West goes to meet Dierdre at midnight,he discovers that she too been slain by unseen assailant.

Strong Bear's Sioux Indians are making noises about breaking the peace treaty. President Grant's first three messengers failed to return from meetings with the Indian leader; now it's up to Jim and Artemus to find Strong Bear and to keep peace in the territory.

On a dusty Californian trail,Jim and Artemus intercept a stagecoach whose driver has been hired to smuggle boll weevils. Quickly theorizing that someone is trying to destroy the country's cotton crop,they set out to find the mastermind of the operation and destroy his distribution system before his plan succeeds.

The Vipers are a gang of ruthless crooks who have been looting a string of Kansas towns,robbing banks and killing citizens. They even robbed the Cottonwood bank while James West was trying to convice the sheriff of the danger. Now the trail leads to Freedom,Kansas,where Jim and Arte must stop the Vipers before the Vipers stop them.

During Mardi Gras West is grabbed by Major Hazard: the leader of a gang of crippled Civil war soldiers seeking revenge on the camp's commandant, Mosely. Jim reluctantly agrees to help them, only to have Mosely taken from him by the soldiers. He tracks them to the abandoned camp, where it turns out that Hazard and his men aren't crippled. They were in league with Mosely, who stole a shipment of gold and hid it. Mosely double-crossed Hazard and his men, so now they want the gold. Thanks to a diversion by Artie (as a geologist who can find gold with a divining rod), Jim escapes and in the ensuing fight, Hazard is killed when the gold falls from its hiding place: the camp's water tower.

The guys become involved with a voodoo ceremony and the walking dead as they try to track down a missing scientist.

A stage coach carrying the western states entire supply of smallpox vaccine is attacked and the drug stolen. Furman Crotty, a convicted criminal serving time in Leavenworth, is demanding his release from jail with a full pardon and a ransom for the safe return of the drug. While Jim West, injured in the attack on the stage, struggles with amnesia, Artemus tries to find both his friend and the drug before a full-scale epidemic hits.

A visit to the plantation of a US Senator reveals a myterious family past that intersects with a doctor infamous for his experiments with apes. The agents are lucky enough to arrive just as the Senator's forgotten giant son and his friend, a giant ape, are rampaging through the plantation.

An attempt to assassinate President Grant is foiled at the last minute by West and Gordon. However,there seems to be more going on than a simple assassination,as the weapon used in the attempt was one stolen in recent raids on government and territorial armories. The President refuses to cancel a trip to Dever,leaving Jim and Artemus only 36 hours to uncover who is responsible and stop them before it's too late.